"The strategy to utilize a simple paper strip for detection is highly commendable. It ensures remarkable portability and budget-friendliness, giving this technology immense scalability potential for deployment in both high-capacity hospitals and…"
"Your vision to create an India-centric genetic marker library is exceptionally well-aligned with the principles of precision medicine, ensuring that the diagnostic tools developed are maximally relevant and effective for the specific patient…"
"The integration of CRISPR-Cas12 with isothermal amplification is a brilliant technological choice, offering a clear path to high-speed, cost-effective, and decentralized cancer detection. This innovative approach directly addresses the financial and…"
"Your presentation is motivating, and the technical angle is solid. On the critical side: what about specificity? Some mutations are shared across cancers or exist in healthy people. You’ll have to carefully pick markers."
"Nice pitch overall. But I wonder about cost breakdowns: even if the device is cheap, reagents (enzymes, guide RNAs) may still be expensive. It’d help to include a rough cost-per-test estimate in your next draft."
"I appreciate the ambition and social impact. But CRISPR-based diagnostics are still cutting edge — there might be stability issues (e.g. shelf life of reagents) when used in rural/field settings. How will you address robustness under varying…"
"Great direction — the national reference library concept is powerful. Yet, you might want to partner with hospitals and research labs early to get clinical samples and validation support rather than trying to collect everything yourselves"
"The idea is strong and well-motivated. One thing to clarify: in which cancer types will you pilot first? Different cancers have very different mutation burdens — narrowing the scope might help you get early wins"
"Very innovative, and the portability aspect is great. A question: how many markers can you reliably test in parallel on a paper strip before the signal gets messy? Scalability might run into technical constraints."
"This is a super cool idea — combining CRISPR, isothermal amplification, and paper strips is very clever. But have you thought about false positives/negatives? You might want to run extensive validation with real patient samples early on to check…"
"An excellent and impactful concept. Building an India-centric genetic marker library using CRISPR technology could significantly improve early cancer detection while making it affordable and accessible. The focus on portability and scalability makes…"
"That's an excellent and well-thought-out concept! The integration of CRISPR-Cas12 with isothermal amplification for a portable and affordable cancer detection system is incredibly innovative. Focusing on an India-centric genetic marker library…"
"This is super cool! Using CRISPR with isothermal amplification and paper strips makes cancer detection cheaper and easier, especially for rural areas."