Ideaz

Problem: Late detections are common for many cancers since the known genetic markers are less in number and their testing is the highest on the cost grid.

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Solution: 

I want to build an India-centric genetic marker library with the help of CRISPR technology.

First, I intend to collect and analyze data from cancer studies made in India and globally. From this we can identify the most frequently and clinically important mutations in cancers that are common in India. 

Using this we prioritize 20-30 key markers for a pilot panel. 

For the interesting part: I introduce CRISPR-Cas12 with isothermal amplification to detect these markers faster and more effectively. 

Isothermal amplification is another way of PCR where the heat is constant and not transferable between hot and cold. This means we don't need any expensive machines. CRISPR-Cas12 works with a guide RNA to look for a particular mutation/marker. 

Detection is read on a simple paper strip making it budget-friendly and portable. 

I want to start with a few markers to validate the product and then scale it.

Scalability for this idea is very high as there can be good collaborations with hospitals, rural clinics, and research labs.

I'm happy to say that this could create a national cancer marker reference for precision medicine.